The classification of diabetes and prediabetes by static glucose thresholds obscures the pathophysiological dysglycemia heterogeneity, primarily driven by insulin resistance (IR), beta-cell dysfunction, and incretin deficiency. This review demonstrates that continuous glucose monitoring and wearable technologies enable a paradigm shift towards non-invasive, dynamic metabolic phenotyping. We show evidence that machine learning models can leverage high-resolution glucose data from at-home, CGM-enabled oral glucose tolerance tests to accurately predict gold-standard measures of muscle IR and beta-cell function. This personalized characterization extends to real-world nutrition, where an individual's unique postprandial glycemic response (PPGR) to standardized meals, such as the relative glucose spike to potatoes versus grapes, could serve as a biomarker for their metabolic subtype. Moreover, integrating wearable data reveals that habitual diet, sleep, and physical activity patterns, particularly their timing, are uniquely associated with specific metabolic dysfunctions, informing precision lifestyle interventions. The efficacy of dietary mitigators in attenuating PPGR is also shown to be phenotype-dependent. Collectively, this evidence demonstrates that CGM can deconstruct the complexity of early dysglycemia into distinct, actionable subphenotypes. This approach moves beyond simple glycemic control, paving the way for targeted nutritional, behavioral, and pharmacological strategies tailored to an individual's core metabolic defects, thereby paving the way for a new era of precision diabetes prevention.

Information retrieval (IR) is the task of finding relevant documents in response to a user query. Although Spanish is the second most spoken native language, current IR benchmarks lack Spanish data, hindering the development of information access tools for Spanish speakers. We introduce MessIRve, a large-scale Spanish IR dataset with around 730 thousand queries from Google's autocomplete API and relevant documents sourced from Wikipedia. MessIRve's queries reflect diverse Spanish-speaking regions, unlike other datasets that are translated from English or do not consider dialectal variations. The large size of the dataset allows it to cover a wide variety of topics, unlike smaller datasets. We provide a comprehensive description of the dataset, comparisons with existing datasets, and baseline evaluations of prominent IR models. Our contributions aim to advance Spanish IR research and improve information access for Spanish speakers.

Tsunamis can trigger internal gravity waves (IGWs) in the ionosphere, perturbing the Total Electron Content (TEC) - referred to as Traveling Ionospheric Disturbances (TIDs) that are detectable through the Global Navigation Satellite System (GNSS). The GNSS are constellations of satellites providing signals from Earth orbit - Europe's Galileo, the United States' Global Positioning System (GPS), Russia's Global'naya Navigatsionnaya Sputnikovaya Sistema (GLONASS) and China's BeiDou. The real-time detection of TIDs provides an approach for tsunami detection, enhancing early warning systems by providing open-ocean coverage in geographic areas not serviceable by buoy-based warning systems. Large volumes of the GNSS data is leveraged by deep learning, which effectively handles complex non-linear relationships across thousands of data streams. We describe a framework leveraging slant total electron content (sTEC) from the VARION (Variometric Approach for Real-Time Ionosphere Observation) algorithm by Gramian Angular Difference Fields (from Computer Vision) and Convolutional Neural Networks (CNNs) to detect TIDs in near-real-time. Historical data from the 2010 Maule, 2011 Tohoku and the 2012 Haida-Gwaii earthquakes and tsunamis are used in model training, and the later-occurring 2015 Illapel earthquake and tsunami in Chile for out-of-sample model validation. Using the experimental framework described in the paper, we achieved a 91.7% F1 score. Source code is available at: https://github.com/vc1492a/tidd. Our work represents a new frontier in detecting tsunami-driven IGWs in open-ocean, dramatically improving the potential for natural hazards detection for coastal communities.